TY  - JOUR
PY  - 2017//
TI  - Abnormalities in kynurenine pathway metabolism in treatment-resistant depression and suicidality: a systematic review
JO  - CNS and neurological disorders drug targets
A1  - Serafini, Gianluca
A1  - Adavastro, Giulia
A1  - Canepa, Giovanna
A1  - Capobianco, Laura
A1  - Conigliaro, Claudia
A1  - Pittaluga, Federica
A1  - Belvederi Murri, Martino
A1  - Valchera, Alessandro
A1  - De Berardis, Domenico
A1  - Pompili, Maurizio
A1  - Lindqvist, Daniel
A1  - Brundin, Lena
A1  - Amore, Mario
SP  - 440
EP  - 453
VL  - 16
IS  - 4
N2  - Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neurobiological determinants underlying these complex conditions, their pathophysiology still remains unclear. Compared to non-suicidal subjects, higher mean concentrations of inflammatory mediators have been found in both the periphery and brain of individuals at risk for suicide. Several lines of evidence suggest that neuroinflammation is accompanied by a dysregulation of the kynurenine pathway (KP) in both TRD and suicidal individuals, resulting in an imbalance of neuroactive metabolites. In particular, neuroinflammation may trigger an increased production of the N-Methyl-D-aspartate (NMDA) receptor agonist quinolinic acid and a concomitant reduction of neuroprotective metabolites, potentially causing downstream effects in glutamatergic systems resulting in depressive symptoms and suicidal behavior. This systematic review of the current literature is mainly aimed at summarizing the most important evidence pertaining to KP metabolism abnormalities in TRD and suicidal behavior. Targeting the KP enzymes may provide innovative approaches in the management of both TRD and suicidality.<br><br>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.<p />  <p>Language: en</p>
LA  - en
SN  - 1871-5273
UR  - http://dx.doi.org/10.2174/1871527316666170413110605
ID  - ref1
ER  -