TY  - JOUR
PY  - 2017//
TI  - Individual differences in fear extinction and anxiety-like behavior
JO  - Learning and memory
A1  - King, Gabrielle
A1  - Scott, Elliot
A1  - Graham, Bronwyn M.
A1  - Richardson, Rick
SP  - 182
EP  - 190
VL  - 24
IS  - 5
N2  - There is growing appreciation for the substantial individual differences in the acquisition and inhibition of aversive associations, and the insights this might give into identifying individuals particularly vulnerable to stress and psychopathology. We examined whether animals that differed in rate of extinction (i.e., Fast versus Slow) were different in their response to an acute stress in adulthood or following a chronic stress that occurred either early or later in life. We found that Slow Extinguishers had significantly poorer extinction retention than Fast Extinguishers, but an acute stressor did not differentially affect anxiety-like behavior in the two groups. Further, while exposure to chronic stress in adulthood did not impact on the extinction phenotypes or anxiety-like behavior, exposure to chronic stress early in life affected both extinction retention and anxiety-like behavior. These findings have implications for the development of a more nuanced approach to identifying those most at risk of anxiety disorders.<br><br>© 2017 King et al.; Published by Cold Spring Harbor Laboratory Press.<p />  <p>Language: en</p>
LA  - en
SN  - 1072-0502
UR  - http://dx.doi.org/10.1101/lm.045021.117
ID  - ref1
ER  -