TY  - JOUR
PY  - 2017//
TI  - Rapid-response impulsivity predicts depression and PTSD symptomatology at 1-year follow-up in blast-exposed service members
JO  - Archives of physical medicine and rehabilitation
A1  - Bjork, James M.
A1  - Burroughs, Thomas K.
A1  - Franke, Laura M.
A1  - Pickett, Treven C.
A1  - Johns, Sade E.
A1  - Moeller, F. Gerard
A1  - Walker, William C.
SP  - 1646
EP  - 1651.e1
VL  - 98
IS  - 8
N2  - OBJECTIVE: To determine if elevated rapid-response impulsivity following blast exposure (as a putative marker of ventral prefrontal cortex (vPFC) damage) is predictive of future elevated affective symptomatology in blast-exposed service members. <br><br>DESIGN: Longitudinal design with neurocognitive testing at initial assessment and one-year follow-up assessment of psychiatric symptomatology by telephone interview. SETTING: Veterans Administration medical centers and post-deployment assessment centers at military bases. PARTICIPANTS: Blast-exposed US military personnel (N=84) age 19-39. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Center for Epidemiological Studies-Depression Scale (CES-D) scores, post-traumatic stress disorder (PTSD) checklist (PCL-5) scores, and Alcohol Use Disorders Identification Test-C (AUDIT-C) scores at the 12-month follow-up telephone interview. <br><br>RESULTS: After controlling for age and affective symptom scores reported at initial assessment, commission errors on the Continuous Performance Test-II of the initial assessment were predictive of higher symptom scores in CES-D and PCL-5 at follow-up, but were not predictive of AUDIT-C scores. <br><br>CONCLUSION: Elevated rapid-response impulsivity, as a behavioral marker of reduced top-down frontocortical control, is a risk factor for elevated mood and PTSD symptoms over time in blast-exposed individuals. Future longitudinal studies with pre-deployment neurobehavioral testing could enable attribution of this relationship to blast-related vPFC damage.<br><br>Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-9993
UR  - http://dx.doi.org/10.1016/j.apmr.2017.03.022
ID  - ref1
ER  -