TY  - JOUR
PY  - 2017//
TI  - Fetal brain injury in complicated monochorionic pregnancies: diagnostic yield of prenatal MRI following surveillance ultrasound and influence on prognostic counselling
JO  - Prenat Diagn
A1  - Robinson, Alice
A1  - Teoh, Mark
A1  - Edwards, Andrew
A1  - Fahey, Michael
A1  - Goergen, Stacy
SP  - 611
EP  - 627
VL  - 37
IS  - 6
N2  - OBJECTIVE: To determine the additional diagnostic information provided by prenatal (fetal) magnetic resonance imaging (pMRI) following tertiary ultrasound (US) for fetal cranial abnormalities in complicated monochorionic gestations (cMCGs) METHODS: Women with cMCGs complicated by twin - twin transfusion syndrome (TTTS), co-twin demise (CD), selective intrauterine growth restriction (sIUGR), and / or twin anemia - polycythemia sequence (TAPS) who were referred for pMRI after tertiary US were included. PRIMARY OUTCOME: additional diagnostic information by pMRI that changed prognostic counselling. <br><br>RESULTS: 33 women with 48 live fetuses had pMRI at a median of 25 weeks (range: 21 - 29). 3/10 survivors of spontaneous CD, 1/8 survivors of CD after TTTS and 1/30 co-survivors had diagnostic information added by pMRI that altered counselling; US was normal in 2 and in the other 3 under- represented parenchymal injury (5/33 = 15%; 95% CI +/- 0.27 - 0.03). Additional findings included occipital lobe infarction, hemispheric injury, dural sinus thrombosis, ischemia producing polymicrogyria, and intraventricular hemorrhage. Another 8 /33 women had additional information provided by pMRI that did not alter counselling. <br><br>CONCLUSION: pMRI resulted in changed prognostic counselling in 5/33 pregnancies. Evaluation of incorporation of pMRI into routine surveillance of complicated MCGs is needed.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1097-0223
UR  - http://dx.doi.org/10.1002/pd.5059
ID  - ref1
ER  -