TY  - JOUR
PY  - 2017//
TI  - Neuropsychiatric symptoms and alzheimer's disease biomarkers predict driving decline: brief report
JO  - Journal of Alzheimer's disease
A1  - Babulal, Ganesh M.
A1  - Stout, Sarah H.
A1  - Head, Denise
A1  - Holtzman, David M.
A1  - Fagan, Anne M.
A1  - Morris, John C.
A1  - Roe, Catherine M.
SP  - 675
EP  - 680
VL  - 58
IS  - 3
N2  - We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-β42 [Aβ42], tau, phosphorylated tau181 [ptau181], tau/Aβ42, and ptau181/Aβ42) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N = 116) aged ≥65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (Aβ42, tau/Aβ42, ptau181/Aβ42) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.<p />  <p>Language: en</p>
LA  - en
SN  - 1387-2877
UR  - http://dx.doi.org/10.3233/JAD-170067
ID  - ref1
ER  -