TY  - JOUR
PY  - 2017//
TI  - Suicide attempt with acetonitrile ingestion in a nursing mother
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - De Capitani, Eduardo Mello
A1  - Borrasca-Fernandes, Carla Fernanda
A1  - Branco Pimenta, Maíra
A1  - Prado, Camila Carbone
A1  - Soubhia, Paula Christiane
A1  - Lanaro, Rafael
A1  - Mello Moreira, Sueli
A1  - Linden, Rafael
A1  - Nóbrega, Helena Valle
A1  - Bucaretchi, Fábio
A1  - Costa, Jose Luiz
SP  - 929
EP  - 933
VL  - 55
IS  - 8
N2  - CONTEXT: Acetonitrile (ACN) is a solvent rapidly absorbed through lungs and intestinal tract, and is slowly metabolized to cyanide (CN) by enzymatic processes mediated by CYP2E1. <br><br>OBJECTIVE: To describe the clinical and laboratory evolution, ACN elimination half-life, and its presence in breast milk in a nursing mother who attempted suicide. CASE DETAILS: A 25-year-old 2-month nursing mother ingested an estimated dose of 2.1 g/kg of ACN. Blood and urine samples were collected 24 h later for ACN, CN and thiocyanate analysis, and 12.5 g sodium thiosulfate i.v. in 1-h infusion was started and repeated every 24 h for 4 days. ACN results showed 200 mg/L in blood and 235 mg/L in urine. ACN analysis in the breast milk at Day 6 showed level of 21 mg/L compared to 27 mg/L in blood collected at the same time, suggesting a possible relationship of 1.3:1.0 ratio. An elimination half-life of 40.4 h was calculated, compared to 32 and 36 h showed in other studies. <br><br>DISCUSSION: The clinical management must involve the use of CN antidotes for more than 24 h depending on the symptoms and blood levels of ACN. Furthermore, our data showed the possible existence of a close relationship between plasma and breast milk levels.<p />  <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650.2017.1324977
ID  - ref1
ER  -