TY  - JOUR
PY  - 2017//
TI  - Multi-system complications after intravenous cocaine abuse
JO  - Open access Macedonian journal of medical sciences
A1  - Petkovska, Lidija
A1  - Chibishev, Andon
A1  - Stevcevska, Aleksandra
A1  - Smokovski, Ivica
A1  - Petkovski, Dusan
A1  - Antova, Emilija
SP  - 231
EP  - 235
VL  - 5
IS  - 2
N2  - BACKGROUND: Use and abuse of cocaine are associated with numerous adverse effects, independent of the route of administration. More severe conditions of poisoning, however, are observed after cocaine intravenous administration. <br><br>AIM: We present a case of severe poisoning after violent intravenous injection of cocaine, but with a good outcome. CASE PRESENTATION: Cocaine was intravenously (i.v.) administered in 16-years old female patient as a homicide attempt. Shortly after that, patient experienced series of generalised tonic-clonic seizures, was highly febrile (40°C), somnolent, agitated, presenting with tachycardia, tachypnea and with increased blood pressure 150/90 mmHg. Neurologic status, lumbar puncture and computerised tomography (CT) of the brain were without remarks. Electroencephalogram (EEG) was characterised with signs of diffuse encephalopathy, and acid-base analyses resulted in metabolic acidosis. Urine screening revealed the presence of cocaine and benzodiazepines. The patient presented with signs of the hepatic lesion, acute renal insufficiency (ARI), and increased D-dimers resulting from activated fibrinolysis. The patient was discharged in stable general condition after being hospitalised for 23 days. <br><br>CONCLUSION: Intravenous abuse of cocaine results in overdose and serous multi-system complications requiring multidisciplinary diagnostic and intensive therapeutic approach.<p />  <p>Language: en</p>
LA  - en
SN  - 1857-9655
UR  - http://dx.doi.org/10.3889/oamjms.2017.046
ID  - ref1
ER  -