TY  - JOUR
PY  - 2017//
TI  - Defining a multimodal signature of remote sports concussions
JO  - European journal of neuroscience
A1  - Tremblay, Sebastien
A1  - Iturria-Medina, Yasser
A1  - Mateos-Pérez, José María
A1  - Evans, Alan C.
A1  - de Beaumont, Louis
SP  - 1956
EP  - 1967
VL  - 46
IS  - 4
N2  - Sports-related concussions lead to persistent anomalies of the brain structure and function that interact with the effects of normal ageing. Although post-mortem investigations have proposed a bio-signature of remote concussions, there is still no clear in vivo signature. In the current study, we characterized white matter integrity in retired athletes with a history of remote concussions by conducting a full-brain, diffusion-based connectivity analysis. Next, we combined MRI diffusion markers with MR spectroscopic, MRI volumetric, neurobehavioral and genetic markers to identify a multidimensional in vivo signature of remote concussions. Machine learning classifiers trained to detect remote concussions using this signature achieved detection accuracies up to 90% (sensitivity: 93%, specificity: 87%). These automated classifiers identified white matter integrity as the hallmark of remote concussions and could provide, following further validation, a preliminary unbiased detection tool to help medical and legal experts rule out concussion history in patients presenting or complaining about late-life abnormal cognitive decline.<br><br>© 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0953-816X
UR  - http://dx.doi.org/10.1111/ejn.13583
ID  - ref1
ER  -