TY  - JOUR
PY  - 2017//
TI  - Heavy metal suicide
JO  - American journal of physiology. Renal physiology
A1  - Linkermann, Andreas
A1  - Stockwell, Brent R.
A1  - Vanden Berghe, Tom
SP  - F959
EP  - F960
VL  - 313
IS  - 4
N2  - In acute kidney injury (AKI), the majority of dying tubular cells succumbs to an iron-dependent form of regulated necrosis, referred to as ferroptosis. Ferroptosis is essentially mediated by iron-catalyzed lipid peroxidation upon GPX4 dysfunction. Heme oxygenase 1 (HO-1) is a master regulator of intracellular free iron due to the conversion of heme to iron, carbon monoxide, and biliverdin(12), and therefore represents a potential regulator of ferroptotic cell death. In this issue of AJP - Renal Physiology, Adedoyin et al. demonstrate that the lack of HO-1 sensitizes renal tubular cells to ferroptosis(1).<br><br>Copyright © 2017, American Journal of Physiology-Renal Physiology.<p />  <p>Language: en</p>
LA  - en
SN  - 1931-857X
UR  - http://dx.doi.org/10.1152/ajprenal.00273.2017
ID  - ref1
ER  -