TY  - JOUR
PY  - 2017//
TI  - Associations between mobility, cognition, and brain structure in healthy older adults
JO  - Frontiers in aging neuroscience
A1  - Demnitz, Naiara
A1  - Zsoldos, Enikő
A1  - Mahmood, Abda
A1  - Mackay, Clare E.
A1  - Kivimaki, Mika
A1  - Singh-Manoux, Archana
A1  - Dawes, Helen
A1  - Johansen-Berg, Heidi
A1  - Ebmeier, Klaus P.
A1  - Sexton, Claire E.
SP  - 155
EP  - 155
VL  - 9
IS  - 
N2  - Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.<p />  <p>Language: en</p>
LA  - en
SN  - 1663-4365
UR  - http://dx.doi.org/10.3389/fnagi.2017.00155
ID  - ref1
ER  -