TY  - JOUR
PY  - 2017//
TI  - Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adult with schizophrenia and bipolar diagnoses
JO  - Brain, behavior, and immunity
A1  - Aas, Monica
A1  - Dieset, Ingrid
A1  - Hope, Sigrun
A1  - Hoseth, Eva
A1  - Mørch, Ragni
A1  - Reponen, Elina
A1  - Steen, Nils Eiel
A1  - Anderssen, Jannicke F.
A1  - Ueland, Thor
A1  - Aukrust, Pål
A1  - Agartz, Ingrid
A1  - Andreassen, Ole A.
A1  - Melle, Ingrid
SP  - 342
EP  - 349
VL  - 65
IS  - 
N2  - BACKGROUND: Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. <br><br>METHODS: The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n=483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs). Plasma levels of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], soluble tumor necrosis factor receptor type 1 [TNFR-R1], glycoprotein 130 [gp130]) were analyzed, and BMI and data on childhood trauma events, on the basis of the Childhood Trauma Questionnaire (CTQ), were obtained from all participants. <br><br>RESULTS: Patients had increased levels of hs-CRP (P<0.001, Cohens d=0.4), lower levels of gp130 (P<0.001, Cohens d=0.5), higher BMI (P<0.001, Cohens d=0.5) and reported more childhood maltreatment experiences (P<0.001, Cohens d=1.2) than the HC group. The severity of childhood abuse (up to three types of abuse: sexual abuse, physical abuse, and emotional abuse) was associated with elevated BMI (f=8.46, P<0.001, Cohen's d=0.5) and hs-CRP (f=5.47, P=0.001, Cohen's d=0.3). Combined effects of patient status and severity of childhood abuse were found for elevated hs-CRP (f=4.76, P<0.001, Cohen's d=0.4). Differences among the groups disappeared when BMI was added to the model. <br><br>DISCUSSION: Trauma-altered immune activation via elevated hs-CRP in patients with SZ and BD may be mediated by higher BMI; however, the direction of this association needs further clarification.<br><br>Copyright © 2017. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0889-1591
UR  - http://dx.doi.org/10.1016/j.bbi.2017.06.005
ID  - ref1
ER  -