TY  - JOUR
PY  - 2017//
TI  - Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer's disease
JO  - International journal of geriatric psychiatry
A1  - Torvinen-Kiiskinen, Sanna
A1  - Tolppanen, Anna-Maija
A1  - Koponen, Marjaana
A1  - Tanskanen, Antti
A1  - Tiihonen, Jari
A1  - Hartikainen, Sirpa
A1  - Taipale, Heidi
SP  - e107
EP  - e115
VL  - 32
IS  - 12
N2  - OBJECTIVE    To study whether antidepressant use is associated with an increased risk of hip fracture among community-dwelling persons with and without Alzheimer's disease (AD), and to compare the risk according to duration of use and between antidepressant groups.     Methods    Retrospective cohort study, including 50,491 persons with AD (mean age 80) and 100,982 comparison persons without AD from Finnish register-based MEDALZ cohort. Antidepressant use was compared with nonuse with Cox proportional hazard models. Incident users were identified with a one year washout period from Prescription register data. Main outcome was hospitalization due to hip fracture.     Results    During antidepressant use, the age-adjusted rate of hip fractures per 100 person-years was 3.01 (95% CI 2.75-3.34) among persons with and 2.28 (1.94-2.61) among persons without AD. Antidepressant use was associated with an increased risk of hip fracture among persons with and without AD (adjusted HR 1.61, 95% CI 1.45-1.80 and 2.71, 2.35-3.14, respectively) compared with nonuse. The risk was most prominent in the beginning of use and was elevated even up to 4 years. The risk was increased with all of the most frequently used antidepressants.     Conclusion    Antidepressant use is associated with an increased risk of hip fracture among older persons. Copyright © 2017 John Wiley & Sons, Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-6230
UR  - http://dx.doi.org/10.1002/gps.4667
ID  - ref1
ER  -