TY  - JOUR
PY  - 2017//
TI  - Traumatic brain injury in a community-based cohort of homeless and vulnerably-housed individuals
JO  - Journal of neurotrauma
A1  - Schmitt, Toby
A1  - Thornton, Allen
A1  - Rawtaer, Iris
A1  - Barr, Alasdair
A1  - Gicas, Kristina M.
A1  - Lang, Donna
A1  - Vertinsky, Talia
A1  - Rauscher, Alexander
A1  - Procyshyn, Ric
A1  - Buchanan, Tari
A1  - Cheng, Alex
A1  - Mackay, Sarah
A1  - Leonova, Olga
A1  - Langheimer, Verena
A1  - Field, Thalia
A1  - Heran, Manraj K. S.
A1  - Vila-Rodriguez, Fidel
A1  - O'Connor, Tiffany-Anne
A1  - MacEwan, William
A1  - Honer, William
A1  - Panenka, William
SP  - 3301
EP  - 3310
VL  - 34
IS  - 23
N2  - We characterized traumatic brain injury (TBI) and studied its associations with mental and physical health in a community cohort of homeless and vulnerably-housed individuals. <br><br>METHODS: Detailed mental and physical health structured interviews, neuropsychological testing, and multimodal MRI were performed on 283 participants. Two traumatic brain injury (TBI) participant groups were defined for primary analyses: those with a self-reported history of TBI and those with MRI evidence of TBI. <br><br>RESULTS: By self-report, 174 participants (61.5%) reported a previous head injury (symptomatic or asymptomatic), with 100 (35.3%) experiencing symptoms consistent with TBI (any post-injury loss of consciousness, confusion or memory loss). Persons self-reporting TBI had poorer current mental and physical health, more ongoing neurological symptoms, and a higher rate of mood disorders, compared with those with no head injury. The presence of a mood disorder, a TBI history, and an interaction between these factors contributed to lower mental health. There was evidence of traumatic brain injury in 20 participants (6.9%) on clinical MRI sequences. These participants had globally lower cortical grey matter volumes and lower white matter fractional anisotropy (FA) values. Neurocognitive test scores positively correlated with both FA and cortical grey matter volumes in participants with MRI evidence of trauma. <br><br>CONCLUSION: Previous TBI is associated with poorer mental and physical health in homeless and vulnerably-housed individuals and interacts with mood disorders to exacerbate poor mental health. Focal traumatic lesions evident on MRI are associated with diffusely lower grey matter volumes and white matter integrity, which predict cognitive functioning.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5076
ID  - ref1
ER  -