TY  - JOUR
PY  - 2018//
TI  - Dynamics of cerebral responses to sustained attention performance during one night of sleep deprivation
JO  - Journal of sleep research
A1  - Zhu, Yuanqiang
A1  - Xi, Yibin
A1  - Fei, Ningbo
A1  - Liu, Yuchen
A1  - Zhang, Xinxin
A1  - Liu, Lin
A1  - Xu, Ziliang
A1  - Sun, Jinbo
A1  - Yang, Xuejuan
A1  - Yin, Hong
A1  - Tian, Jie
A1  - Qin, Wei
SP  - 184
EP  - 196
VL  - 27
IS  - 2
N2  - Total sleep deprivation (TSD) is increasingly common in modern society bringing various neurobehavioural effects. Dynamic changes of behaviour performances during TSD have been reported extensively, while the cerebral activation underlying such changes have not been elucidated clearly. This study aimed to investigate dynamic changes in cerebral responses to the fastest and slowest psychomotor vigilance task (PVT) trials during TSD. Thirty-six healthy subjects with intermediate chronotype performed the PVT while undergoing functional magnetic resonance imaging every 2 h from 22:00 hours on the first day to 06:00 hours on the second day (i.e. 22:00, 12:00, 02:00, 04:00 and 06:00 hours; a total of five imaging sessions). Behaviourally, significant time effects were found for the PVT performance. For imaging results, significant activation alterations were found in the cognitive control network and the default mode network (DMN) for the fastest and slowest PVT trials, respectively. Time-course analysis indicated that the largest differences for behavioural results and imaging results happened in session 4 and became more prominent in session 5. Our findings provide more detailed information about the process of sustained attention activation during one night of TSD and add information regarding the effect of circadian rhythmicity and homeostatic sleep pressure on regional brain responses.<br><br>© 2017 European Sleep Research Society.<p />  <p>Language: en</p>
LA  - en
SN  - 0962-1105
UR  - http://dx.doi.org/10.1111/jsr.12582
ID  - ref1
ER  -