TY  - JOUR
PY  - 2018//
TI  - On-road assessment of fitness-to-drive in persons with MS with cognitive impairment: a prospective study
JO  - Multiple Sclerosis: Clinical and Laboratory Research
A1  - Morrow, Sarah A.
A1  - Classen, Sherrilene
A1  - Monahan, Miriam
A1  - Danter, Tim
A1  - Taylor, Robert
A1  - Krasniuk, Sarah
A1  - Rosehart, Heather
A1  - He, Wenqing
SP  - 1499
EP  - 1506
VL  - 24
IS  - 11
N2  - BACKGROUND: Cognitive impairment is common in multiple sclerosis (MS). In other populations, cognitive impairment is known to affect fitness-to-drive. Few studies have focused on fitness-to-drive in MS and no studies have solely focused on the influence of cognitive impairment. <br><br>OBJECTIVE: To assess fitness-to-drive in persons with MS with cognitive impairment and low physical disability. <br><br>METHODS: Persons with MS, aged 18-59 years with EDSS ⩽ 4.0, impaired processing speed, and impairment on at least one measure of memory or executive function, were recruited. Cognition was assessed using the Minimal Assessment of Cognitive Function battery. A formal on-road driving assessment was conducted. Chi-square analysis examined the association between the fitness-to-drive (pass/fail) and the neuropsychological test results (normal/impaired). Bayesian statistics predicting failure of the on-road assessment were calculated. <br><br>RESULTS: Of 36 subjects, eight (22.2%) were unfit to drive. Only the BVMTR-IR, measuring visual-spatial memory, predicted on-road driving assessment failure ( X(2) ( df = 1, N = 36) = 3.956; p = 0.047) with a sensitivity of 100%, but low specificity (35.7%) due to false positives (18/25). <br><br>CONCLUSION: In persons with MS and impaired processing speed, impairment on the BVMTR-IR should lead clinicians to address fitness-to-drive.<p />  <p>Language: en</p>
LA  - en
SN  - 1352-4585
UR  - http://dx.doi.org/10.1177/1352458517723991
ID  - ref1
ER  -