TY  - JOUR
PY  - 2017//
TI  - Slow gait speed is associated with executive function decline in older people with mild to moderate dementia: a one year longitudinal study
JO  - Archives of gerontology and geriatrics
A1  - Taylor, Morag E.
A1  - Lasschuit, Danielle A.
A1  - Lord, Stephen R.
A1  - Delbaere, Kim
A1  - Kurrle, Susan E.
A1  - Mikolaizak, A. Stefanie
A1  - Kvelde, Tasha
A1  - Close, Jacqueline C. T.
SP  - 148
EP  - 153
VL  - 73
IS  - 
N2  - OBJECTIVES: This study aimed to document change in neuropsychological, physical and functional performance over one year and to investigate the relationship between baseline gait speed and cognitive decline in this period in older people with dementia. <br><br>METHODS: One hundred and seventy-seven older people with dementia (Mini-Mental State Examination 11-23; Addenbrooke's Cognitive Examination-Revised <83) residing in the community or low level care facility completed baseline neuropsychological, physical and functional assessments. Of these, 134 participants agreed to reassessment of the above measures one year later. <br><br>RESULTS: Overall, many neuropsychological, physical and functional performance measures declined significantly over the one year study period. Baseline gait speed was significantly associated with decline in verbal fluency (B(109)=2.893, p=0.046), specifically phonemic/letter fluency (B(109)=2.812, p=0.004) while controlling for age, education, dementia drug use and baseline cognitive performance. There was also a trend for an association between baseline gait speed and decline in clock drawing performance (B(107)=0.601, p=0.071). <br><br>CONCLUSIONS: Older people with mild to moderate dementia demonstrate significant decline in neuropsychological, physical and functional performance over one year. Baseline gait speed is associated with decline in executive function over one year, suggesting shared pathways/pathology between gait and cognition.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0167-4943
UR  - http://dx.doi.org/10.1016/j.archger.2017.07.023
ID  - ref1
ER  -