TY  - JOUR
PY  - 2017//
TI  - Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017)
JO  - Journal of child psychology and psychiatry
A1  - White, Lars O.
A1  - Ising, Marcus
A1  - von Klitzing, Kai
A1  - Sierau, Susan
A1  - Michel, Andrea
A1  - Klein, Annette M.
A1  - Müller-Myhsok, Bertram
A1  - Uhr, Manfred
A1  - Crowley, Michael J.
A1  - Kirschbaum, Clemens
A1  - Stalder, Tobias
SP  - 1011
EP  - 1013
VL  - 58
IS  - 9
N2  - We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view.<br><br>© 2017 Association for Child and Adolescent Mental Health.<p />  <p>Language: en</p>
LA  - en
SN  - 0021-9630
UR  - http://dx.doi.org/10.1111/jcpp.12770
ID  - ref1
ER  -