TY  - JOUR
PY  - 1982//
TI  - Proserotoninergic agents and depression (author's transl)
JO  - L'Encephale (1974)
A1  - Uzan, A.
SP  - 273
EP  - 289
VL  - 8
IS  - 2
N2  - The proserotoninergic hypothesis of depression has been for a long time founded on biochemical parameters (brain from suicide patients, CSF and plasma from depressed patients) or more recently on measurement of platelets 5-HT uptake or imipramine binding. New specific proserotoninergic agents confirm this hypothesis since indalpine, a specific 5-HT uptake inhibitor, has a neurochemical and pharmacological profile characteristics of proserotoninergic agents and is effectively antidepressant in human. 5-HT uptake inhibition seems an important property because when we compared two isomers one, a 5-HT uptake inhibitor and at the same time 5-HT releaser, and the other only releaser, we observed that the first has experimental properties similar to indalpine whereas the second has not the classical spectrum of a proserotoninergic agent.<p /> <p>Language: fr</p>
LA  - fr
SN  - 0013-7006
UR  - http://dx.doi.org/
ID  - ref1
ER  -