TY  - JOUR
PY  - 2017//
TI  - Preliminary evidence that reactivity to uncertain threat is an endophenotype for alcohol use disorder
JO  - Drug and alcohol dependence
A1  - Gorka, Stephanie M.
A1  - Shankman, Stewart A.
SP  - 265
EP  - 271
VL  - 180
IS  - 
N2  - BACKGROUND: Having an exaggerated reactivity to threats that are uncertain (U-threat) may facilitate the initiation and maintenance of excessive alcohol use in some individuals. This abnormality may not just be a concomitant for alcohol use disorder (AUD), but also an endophenotype for AUD. <br><br>METHOD: The aim of the current study was therefore to provide a preliminary test of whether U-threat is an endophenotype for AUD using several of the endophenotype criteria outlined by Gottesman and Gould (2003). Specifically, the study examined whether heightened U-threat reactivity is evidenced in those with: 1) current AUD; 2) remitted AUD (early and sustained remission examined separately); and 3) at-risk for AUD by virtue of having a positive family history of AUD. Participants (N = 147) completed a well-validated threat-of-shock task and startle eyeblink potentiation was collected as an index of aversive responding. Individuals and all available first-degree family members were diagnosed using structured clinical interviews. <br><br>RESULTS: Individuals at-risk for AUD, with current AUD, and AUD in remission (both early and sustained) all displayed exaggerated reactivity to U-threat, but not predictable threat, compared with non-AUD controls. Moreover, there were no significant differences between the at-risk and any of the AUD groups indicating that exaggerated reactivity to U-threat is relatively state-independent and present regardless of current AUD disease status. <br><br>CONCLUSIONS: The findings together highlight that exaggerated reactivity to U-threat may be a promising endophenotype for AUD that can aid in the refinement of mechanistic AUD disease models.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2017.08.023
ID  - ref1
ER  -