TY  - JOUR
PY  - 2018//
TI  - Concussion alters the functional brain processes of visual attention and working memory
JO  - Journal of neurotrauma
A1  - Shah-Basak, Priyanka
A1  - Urbain, Charline
A1  - Wong, Simeon
A1  - Da Costa, Leodante
A1  - Pang, Elizabeth W.
A1  - Dunkley, Benjamin
A1  - Taylor, Margot
SP  - 267
EP  - 277
VL  - 35
IS  - 2
N2  - Millions of North Americans suffer a concussion or a mild traumatic brain injury annually and are at risk of cognitive, emotional and physical sequelae. While fMRI studies have provided an initial framework for examining functional deficits induced by concussion, particularly working memory and attention, the temporal dynamics underlying these deficits are not well understood. We used magnetoencephalography (MEG), a modality with millisecond temporal resolution, in conjunction with a 1-back visual working memory (VWM) paradigm using scenes from everyday life to characterize spatiotemporal functional differences at specific VWM stages, in adults who did or did not suffer a recent concussion. MEG source-level differences between groups were determined by whole-brain analyses during encoding and recognition phases. Despite comparable behavioural performance, abnormal hypo- and hyperactivation patterns were found in brain areas involving frontoparietal, ventral occipitotemporal, temporal and subcortical areas in concussed patients. These patterns and their timing varied as a function of VWM stage-wise processing, linked to early attentional control, visuoperceptual scene processing and VWM maintenance and retrieval processes. Parietal hypoactivation, starting at 60ms during encoding, was correlated with symptom severity, possibly linked to impaired top-down attentional processing. Hyperactivation in the scene-selective occipitotemporal areas, the medial temporal complex, specifically the right hippocampus and orbitofrontal areas during encoding and/or recognition, lead us to posit inefficient but compensatory visuoperceptual, relational and retrieval processing. Although injuries sustained after the concussion were considered 'mild', these data suggest that they can have prolonged effects on early attentional and VWM processes.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5117
ID  - ref1
ER  -