TY  - JOUR
PY  - 2017//
TI  - Adverse reaction with suvorexant for insomnia: acute worsening of depression with emergence of suicidal thoughts
JO  - BMJ case reports
A1  - Petrous, Jeremy
A1  - Furmaga, Kevin
SP  - e222037
EP  - e222037
VL  - 2017
IS  - 
N2  - A 59-year-old woman on daily peritoneal dialysis for end-stage renal failure received care at an outpatient psychiatric clinic for her diagnoses that include major depressive disorder, generalised anxiety disorder and insomnia disorder. Although there was partial improvement in the patient's mood and anxiety symptoms with antidepressant treatment, insomnia remained a persistent complaint despite adequate trials of different sleep medications. The novel hypnotic, suvorexant (Belsomra, Merck & Co.) was then initiated at the recommended bedtime dose of 10 mg and was followed by a 15 mg dose the following night. Within an hour after taking her second suvorexant dose, the severity of patient's depression symptoms worsened and was accompanied by new onset of suicidal thoughts.<br><br>© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.<p />  <p>Language: en</p>
LA  - en
SN  - 1757-790X
UR  - http://dx.doi.org/10.1136/bcr-2017-222037
ID  - ref1
ER  -