TY  - JOUR
PY  - 2017//
TI  - Biochemical diagnosis in substance and non-substance addiction
JO  - Advances in experimental medicine and biology
A1  - Shen, Wenwen
A1  - Liu, Huifeng
A1  - Xie, Xiaohu
A1  - Liu, Haixiong
A1  - Zhou, Wenhua
SP  - 169
EP  - 202
VL  - 1010
IS  - 
N2  - An optimal biochemical marker for addiction would be some easily traced molecules in body specimens, which indicates indulgent addictive behaviors, or susceptibility to certain addictive stimuli. In this chapter, we discussed existing literature about possible biomarkers, and classified them into three categories: origin forms and metabolites of substances, markers from biochemical responses to certain addiction, and genetic and epigenetic biomarkers suggesting susceptibility to addiction. In every category, we examined studies concerning certain type of addiction one by one, with focuses mainly on opiates, psychostimulants, and pathological gambling. Several promising molecules were highlighted, including those of neurotrophic factors, inflammatory factors, and indicators of vascular injury, and genetic and epigenetic biomarkers such as serum miRNAs. DNA methylation signatures and signal nucleotide polymorphism of candidate gene underlying the addiction.<p />  <p>Language: en</p>
LA  - en
SN  - 0065-2598
UR  - http://dx.doi.org/10.1007/978-981-10-5562-1_9
ID  - ref1
ER  -