TY  - JOUR
PY  - 2017//
TI  - Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke
JO  - Medicine (Baltimore)
A1  - Yang, Mengmeng
A1  - Li, Zhi
A1  - Zhao, Yan
A1  - Zhou, Feihu
A1  - Zhang, Yu
A1  - Gao, Jingli
A1  - Yin, Ting
A1  - Hu, Xin
A1  - Mao, Zhi
A1  - Xiao, Jianguo
A1  - Wang, Li
A1  - Liu, Chao
A1  - Ma, Liqiong
A1  - Yuan, Zhihao
A1  - Lv, Jianfei
A1  - Shen, Haoliang
A1  - Hou, Peter C.
A1  - Kang, Hongjun
SP  - e8417
EP  - e8417
VL  - 96
IS  - 44
N2  - To explore the relationship between the extent of central nervous system (CNS) injury and patient outcomes meanwhile research the potential risk factors associated with neurologic sequelae. In this retrospective cohort study, we analyzed data from 117 consecutive patients (86 survivors, 31 nonsurvivors) with exertional heat stroke (EHS) who had been admitted to intensive care unit (ICU) at 48 Chinese hospitals between April 2003 and July 2015. Extent of CNS injury was dichotomized according to Glasgow coma scale (GCS) score (severe 3-8, not severe 9-15). We then assessed differences in hospital mortality based on the extent of CNS injury by comparing 90-day survival time between the patient groups. Exploring the risk factors of neurologic sequelae. The primary outcomewas the 90-day survival ratewhich differed between the 2 groups (P = .023). The incidence of neurologic sequelae was 24.4%. For its risk factors, duration of recurrent hyperthermia (OR = 1.73, 95% CI: 1.20-2.49, P = .003), duration of CNS injury (OR = 1.39, 95% CI: 1.04-1.85, P = .025), and low GCS in the first 24 hours after admission (OR = 2.39, 95% CI: 1.11-5.15, P = .025) were selected by multivariable logistic regression. Cooling effect was eliminated as a factor (OR = 2641.27, 95% CI 0.40-1.73_107, P = .079). Significant differences in 90-day survival ratewere observed based on the extent of CNS injury in patients with EHS, and incidence was 24.4% for neurologic sequelae. Duration of recurrent hyperthermia, duration of CNS injury, and low GCS score in the first 24 hours following admission may be independent risk factors of neurologic sequelae. Cooling effect should be validated in the further studies.<p />  <p>Language: en</p>
LA  - en
SN  - 0025-7974
UR  - http://dx.doi.org/10.1097/MD.0000000000008417
ID  - ref1
ER  -