TY  - JOUR
PY  - 2018//
TI  - Single severe traumatic brain injury produces progressive pathology with ongoing contralateral white matter damage one year after injury
JO  - Experimental neurology
A1  - Pischiutta, Francesca
A1  - Micotti, Edoardo
A1  - Hay, Jennifer R.
A1  - Marongiu, Ines
A1  - Sammali, Eliana
A1  - Tolomeo, Daniele
A1  - Vegliante, Gloria
A1  - Stocchetti, Nino
A1  - Forloni, Gianluigi
A1  - De Simoni, Maria-Grazia
A1  - Stewart, William
A1  - Zanier, Elisa R.
SP  - 167
EP  - 178
VL  - 300
IS  - 
N2  - There is increasing recognition that traumatic brain injury (TBI) may initiate long-term neurodegenerative processes, particularly chronic traumatic encephalopathy. However, insight into the mechanisms transforming an initial biomechanical injury into a neurodegenerative process remain elusive, partly as a consequence of the paucity of informative pre-clinical models. This study shows the functional, whole brain imaging and neuropathological consequences at up to one year survival from single severe TBI by controlled cortical impact in mice. TBI mice displayed persistent sensorimotor and cognitive deficits. Longitudinal T2 weighted magnetic resonance imaging (MRI) showed progressive ipsilateral (il) cortical, hippocampal and striatal volume loss, with diffusion tensor imaging demonstrating decreased fractional anisotropy (FA) at up to one year in the il-corpus callosum (CC: -30%) and external capsule (EC: -21%). Parallel neuropathological studies indicated reduction in neuronal density, with evidence of microgliosis and astrogliosis in the il-cortex, with further evidence of microgliosis and astrogliosis in the il-thalamus. One year after TBI there was also a decrease in FA in the contralateral (cl) CC (-17%) and EC (-13%), corresponding to histopathological evidence of white matter loss (cl-CC: -68%; cl-EC: -30%) associated with ongoing microgliosis and astrogliosis. These findings indicate that a single severe TBI induces bilateral, long-term and progressive neuropathology at up to one year after injury. These observations support this model as a suitable platform for exploring the mechanistic link between acute brain injury and late and persistent neurodegeneration.<br><br>Copyright © 2017. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0014-4886
UR  - http://dx.doi.org/10.1016/j.expneurol.2017.11.003
ID  - ref1
ER  -