TY  - JOUR
PY  - 2018//
TI  - Cognitive enhancers associated with decreased risk of injury in patients with dementia: a nationwide cohort study in Taiwan
JO  - Journal of investigative medicine
A1  - Chao, Pei-Chun
A1  - Chien, Wu-Chien
A1  - Chung, Chi-Hsiang
A1  - Chu, Ching-Wen
A1  - Yeh, Chin-Bin
A1  - Huang, San-Yuan
A1  - Lu, Ru-Band
A1  - Chang, Hsin-An
A1  - Kao, Yu-Chen
A1  - Yeh, Hui-Wen
A1  - Chiang, Wei-Shan
A1  - Chou, Yu-Ching
A1  - Tzeng, Nian-Sheng
SP  - 684
EP  - 692
VL  - 66
IS  - 3
N2  - This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients ≥age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000-2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury.<br><br>© American Federation for Medical Research (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.<p />  <p>Language: en</p>
LA  - en
SN  - 1081-5589
UR  - http://dx.doi.org/10.1136/jim-2017-000595
ID  - ref1
ER  -