TY  - JOUR
PY  - 2018//
TI  - A multimodal mri study of recovery of consciousness in severe traumatic brain injury: preliminary results
JO  - Journal of neurotrauma
A1  - Yang, Ang
A1  - Xiao, Xue Hong
A1  - Liu, Zhong Hua
A1  - Wan, Zhi Long
A1  - Wang, Ze Yan
SP  - 308
EP  - 313
VL  - 35
IS  - 2
N2  - Accurate and reliable assessment of the conscious state of patients with severe TBI is vital for their future management. The purpose of the present study is to find an effective and accurate magnetic resonance imaging (MRI) method for predicting recovery of consciousness in patients with severe traumatic brain injury (TBI). Multimodal MR techniques, including structural MRI, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), were used to evaluate brain damage in 58 patients with severe TBI. Statistical analysis compared imaging results and recovery over a relatively long period to find the most potent prognostic indicators and predictive method. Total 33 patients gained recovery of consciousness (RC), and 25 did not (NRC). Comparing with RC, NRC had a significantly lower NAA/Cr of pons (1.43 ± 0.54 vs. 1.70 ± 0.42), more fiber lines (1046.3± 100.8 vs.975.6 ± 128.1), less pgrey (579.23±78.85 vs. 638.23±61.16), lower FA of fibers (0.42 ± 0.04 vs. 0.45 ± 0.03), older age (43.08± 14.61 vs. 30.57 ± 12.89) and higher ADC of fibers (0.99 ± 0.14 vs. 0.89 ±0.06); all P<0.05. Age, Pgrey, ADC of fibers, NAA/Cr of pons were selected by logistic regression analysis to predict RC, with P-values of 0.033 and 0.031, 0.035, 0.030 respectively. Age, Pgrey, ADC of fibers, NAA/Cr of pons are effective indicators in predictive model of RC.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5335
ID  - ref1
ER  -