TY  - JOUR
PY  - 2017//
TI  - RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior
JO  - European Neuropsychopharmacology
A1  - Fernàndez-Castillo, Noèlia
A1  - Gan, Gabriela
A1  - van Donkelaar, Marjolein M. J.
A1  - Vaht, Mariliis
A1  - Weber, Heike
A1  - Retz, Wolfgang
A1  - Meyer-Lindenberg, Andreas
A1  - Franke, Barbara
A1  - Harro, Jaanus
A1  - Reif, Andreas
A1  - Faraone, Stephen V.
A1  - Cormand, Bru
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The RBFOX1 gene (or A2BP1) encodes a splicing factor important for neuronal development that has been related to autism spectrum disorder and other neurodevelopmental phenotypes. Evidence from complementary sources suggests that this gene contributes to aggressive behavior. Suggestive associations with RBFOX1 have been identified in genome-wide association studies (GWAS) of anger, conduct disorder, and aggressive behavior. Nominal association signals in RBFOX1 were also found in an epigenome-wide association study (EWAS) of aggressive behavior. Also, variants in this gene affect temporal lobe volume, a brain area that is altered in several aggression-related phenotypes. In animals, this gene has been shown to modulate aggressive behavior in Drosophila. RBFOX1 has also been associated with canine aggression and is upregulated in mice that show increased aggression after frustration of an expected reward. Associated common genetic variants as well as rare duplications and deletions affecting RBFOX1 have been identified in several psychiatric and neurodevelopmental disorders that are often comorbid with aggressive behaviors. In this paper, we comprehensively review the cumulative evidence linking RBFOX1 to aggression behavior and provide new results implicating RBFOX1 in this phenotype. Most of these studies (genetic and epigenetic analyses in humans, neuroimaging genetics, gene expression and animal models) are hypothesis-free, which strengthens the validity of the findings, although all the evidence is nominal and should therefore be taken with caution. Further studies are required to clarify in detail the role of this gene in this complex phenotype.<br><br>Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2017.11.012
ID  - ref1
ER  -