TY  - JOUR
PY  - 2018//
TI  - Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians
JO  - Psychopharmacology
A1  - Wardzala, Casia
A1  - Murchison, Charles
A1  - Loftis, Jennifer M.
A1  - Schenning, Katie J.
A1  - Mattek, Nora
A1  - Woltjer, Randall
A1  - Kaye, Jeff
A1  - Quinn, Joseph F.
A1  - Wilhelm, Clare J.
SP  - 761
EP  - 770
VL  - 235
IS  - 3
N2  - RATIONALE: The beneficial effects of moderate alcohol may differ in aging men versus women. <br><br>OBJECTIVES: Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. <br><br>METHODS: Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. <br><br>RESULTS: Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5-6) Braak NFT stage in men (p < 0.05), with no effect in women. <br><br>CONCLUSIONS: In this cohort, men experienced a broader range of beneficial effects associated with alcohol. Alcohol's effects may differ in men and women in important ways that suggest a narrower beneficial window.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-3158
UR  - http://dx.doi.org/10.1007/s00213-017-4791-6
ID  - ref1
ER  -