TY  - JOUR
PY  - 2017//
TI  - Epigenetic profiles associated with major depression in the human brain
JO  - Psychiatry research
A1  - Bustamante, Angela C.
A1  - Armstrong, Don L.
A1  - Uddin, Monica
SP  - 439
EP  - 442
VL  - 260
IS  - 
N2  - We conducted an epigenome-wide association study of Major Depressive Disorder (MDD) in brain-derived DNA using two analytic approaches. DNA methylation data (GSE41826) was used in differential methylation (DM) analyses controlling for age, sex, suicide status, and post-mortem interval; and in weighted gene co-methylation network analyses (WGCNA) in probes mapping to transcription start sites. No probes in the DM analysis survived FDR correction. Nominally significant DM probes were enriched in synaptic function-related genes. WGCNA revealed one module correlated with MDD, enriched in genes associated with mitochondrial function. DM and WGCNA both showed enrichment of genes involved in transcription and DNA binding.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2017.12.010
ID  - ref1
ER  -