TY  - JOUR
PY  - 2018//
TI  - Serotonin transporter gene expression predicts the worsening of suicidal ideation and suicide attempts along a long-term follow-up of a major depressive episode
JO  - European Neuropsychopharmacology
A1  - Consoloni, Julia-Lou
A1  - Ibrahim, El Chérif
A1  - Lefebvre, Marie-Noëlle
A1  - Zendjidjian, Xavier
A1  - Olié, Emilie
A1  - Mazzola-Pomietto, Pascale
A1  - Desmidt, Thomas
A1  - Samalin, Ludovic
A1  - Llorca, Pierre-Michel
A1  - Abbar, Mocrane
A1  - Lopez-Castroman, Jorge
A1  - Haffen, Emmanuel
A1  - Baumstarck, Karine
A1  - Naudin, Jean
A1  - Azorin, Jean-Michel
A1  - El-Hage, Wissam
A1  - Courtet, Philippe
A1  - Belzeaux, Raoul
SP  - 401
EP  - 414
VL  - 28
IS  - 3
N2  - The quest for biomarkers in suicidal behaviors has been elusive so far, despite their potential utility in clinical practice. One of the most robust biological findings in suicidal behaviors is the alteration of the serotonin transporter function in suicidal individuals. Our main objective was to investigate the predictive value of the serotonin transporter gene expression (SLC6A4) for suicidal ideation and as secondary, for suicide attempts in individuals with a major depressive episode (MDE). A 30-week prospective study was conducted on 148 patients with a MDE and 100 healthy controls including 4 evaluation times (0, 2, 8 and 30 weeks). Blood samples and clinical data were collected and SLC6A4 mRNA levels were measured from peripheral blood mononuclear cells using RT-qPCR. We first demonstrated the stability and reproducibility of SLC6A4 mRNA expression measures over time in healthy controls (F=0.658; p=0.579; η2=0.008; ICC=0.91, 95% CI [0.87-0.94]). Baseline SLC6A4 expression level (OR=0.563 [0.340-0.932], p=0.026) as well as early changes in SLC6A4 expression between baseline and the 2nd week (β=0.200, p=0.042) predicted the worsening of suicidal ideation (WSI) in the following 8 weeks. Moreover, changes in SLC6A4 expression between the 2nd and 8th weeks predicted the occurrence of a suicide attempt within 30 weeks (OR=10.976 [1.438-83.768], p=0.021). Altogether, the baseline level and the changes in SLC6A4 mRNA expression during a MDE might predict the WSI and the occurrence of suicidal attempts and could be a useful biomarker in clinical practice.<br><br>Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2017.12.015
ID  - ref1
ER  -