TY  - JOUR
PY  - 2018//
TI  - The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease
JO  - Parkinsonism and related disorders
A1  - van Uem, Janet M. T.
A1  - Cerff, Bernhard
A1  - Kampmeyer, Malte
A1  - Prinzen, Jos
A1  - Zuidema, Menno
A1  - Hobert, Markus A.
A1  - Gräber, Susanne
A1  - Berg, Daniela
A1  - Maetzler, Walter
A1  - Liepelt-Scarfone, Inga
SP  - 74
EP  - 81
VL  - 48
IS  - 
N2  - BACKGROUND: Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD. <br><br>METHODS: Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL). <br><br>RESULTS: Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL. <br><br>DISCUSSION: For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.<br><br>Copyright © 2017. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 1353-8020
UR  - http://dx.doi.org/10.1016/j.parkreldis.2017.12.023
ID  - ref1
ER  -