TY  - JOUR
PY  - 2018//
TI  - Exposure to ambient air particles increases the risk of mental disorder: findings from a natural experiment in Beijing
JO  - International journal of environmental research and public health
A1  - Jia, Zhen
A1  - Wei, Yongjie
A1  - Li, Xiaoqian
A1  - Yang, Lixin
A1  - Liu, Huijie
A1  - Guo, Chen
A1  - Zhang, Lulu
A1  - Li, Nannan
A1  - Guo, Shaojuan
A1  - Qian, Yan
A1  - Li, Zhigang
SP  - e15010160
EP  - e15010160
VL  - 15
IS  - 1
N2  - Epidemiology studies indicated that air pollution has been associated with adverse neurological effects in human. Moreover, the secretion of glucocorticoid (GC) affects the mood regulation, and the negative feedback of hippocampal glucocorticoid receptors (GR) inhibits the GC secretion. Meanwhile, the over secretion of GC can interfere the immune system and induce neurotoxicity. In the present study, the human test showed that the secretion of the cortisol in plasma was elevated after exposure in heavy air pollution. In the mouse model, we found that breathing the highly polluted air resulted in the negative responses of the mood-related behavioral tests and morphology of hippocampus, as well as the over secretion of GC in plasma, down regulation of GR, and up-regulation of cytokine and chemokine in the hippocampus. When considering the interrelated trends between the hippocampal GR, inflammatory factors, and plasmatic GC, we speculated that PM2.5 exposure could lead to the increased secretion of GC in plasma by decreasing the expression of GR in hippocampus, which activated the inflammation response, and finally induced neurotoxicity, suggesting that PM2.5 exposure negatively affects mood regulation. When combined with the results of the human test, it indicated that exposure to ambient air particles increased the risk of mental disorder.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-7827
UR  - http://dx.doi.org/10.3390/ijerph15010160
ID  - ref1
ER  -