TY  - JOUR
PY  - 2018//
TI  - The risk of traumatic brain injury occurring among patients with Parkinson'sdisease: a 14-year population-based study
JO  - World neurosurgery
A1  - Eric Nyam, Tee-Tau
A1  - Ho, Chung-Han
A1  - Wang, Yu-Lin
A1  - Lim, Sher-Wei
A1  - Wang, Jhi-Joung
A1  - Chio, Chung-Ching
A1  - Kuo, Jinn-Rung
A1  - Wang, Che-Chuan
SP  - e328
EP  - e335
VL  - 113
IS  -  
N2  - BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson's disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. MATERIAL AND METHODS: The study selected 6,076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan.The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted with the potential confounding factors. <br><br>RESULTS: The incidence of TBI in patients with PD (2.57%) and compared cohorts (1.81%) was significantly different (p=.0007). Patients with PD had a higher risk ofTBI (HR =1.63; 95% confidence interval [CI], 1.32-2.01) compared to the general population.Patients with PD with TBI incidence had a higher Charlson'scomorbidity index score than the general population with TBI outcome (p<.0001). Fall is the major cause of TBI in patients with PD. <br><br>CONCLUSIONS: This study demonstrated that patients with PDhave a highrisk of TBI, andthe major cause of TBI in patients with PD is fall.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1878-8750
UR  - http://dx.doi.org/10.1016/j.wneu.2018.02.027
ID  - ref1
ER  -