TY  - JOUR
PY  - 2018//
TI  - An in vitro model of traumatic brain injury
JO  - Methods in molecular biology
A1  - Salvador, Ellaine
A1  - Burek, Malgorzata
A1  - Förster, Carola Y.
SP  - 219
EP  - 227
VL  - 1717
IS  - 
N2  - Traumatic brain injury (TBI) is a significant problem causing high mortality globally. <br><br>METHODS to increase possibilities for treatment and prevention of secondary injuries resulting from the initial physical insult are thus much needed. TBI affects the central nervous system (CNS) and the neurovascular unit as a whole in numerous ways but one of the primarily compromised components is the blood-brain barrier (BBB).In this chapter, we present a detailed procedure on how stretch injury and oxygen-glucose deprivation (OGD) are applied to brain microvascular endothelial cells of the BBB in order to replicate the actual impact they receive during TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 1064-3745
UR  - http://dx.doi.org/10.1007/978-1-4939-7526-6_17
ID  - ref1
ER  -