TY  - JOUR
PY  - 2017//
TI  - Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos
JO  - Journal of psychiatric research
A1  - Dunn, Erin C.
A1  - Sofer, Tamar
A1  - Wang, Min-Jung
A1  - Soare, Thomas W.
A1  - Gallo, Linda C.
A1  - Gogarten, Stephanie M.
A1  - Kerr, Kathleen F.
A1  - Chen, Chia-Yen
A1  - Stein, Murray B.
A1  - Ursano, Robert J.
A1  - Guo, Xiuqing
A1  - Jia, Yucheng
A1  - Yao, Jie
A1  - Rotter, Jerome I.
A1  - Argos, Maria
A1  - Cai, Jianwen
A1  - Perreira, Krista M.
A1  - Wassertheil-Smoller, Sylvia
A1  - Smoller, Jordan W.
SP  - 167
EP  - 176
VL  - 99
IS  - 
N2  - Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users. We estimated heritability due to common variants (h<sup>2</sup><sub>SNP</sub>), and performed a GWAS of the three phenotypes. Replication was attempted in three independent Hispanic/Latino cohorts. We also performed sex-stratified analyses, analyzed a binary trait indicating probable depression, and conducted three trans-ethnic analyses. The three phenotypes exhibited significant heritability (h<sup>2</sup><sub>SNP</sub> = 6.3-6.9%; p = .002) in the total sample. No SNPs were genome-wide significant in analyses of the three phenotypes or the binary indicator of probable depression. In sex-stratified analyses, seven genome-wide significant SNPs (one in females; six in males) were identified, though none were supported through replication. Four out of 24 loci identified in prior GWAS were nominally associated in HCHS/SOL. There was no evidence of overlap in genetic risk factors across ancestry groups, though this may have been due to low power. We conducted the largest GWAS of depression-related phenotypes in Hispanic/Latino adults. <br><br>RESULTS underscore the genetic complexity of depressive symptoms as a phenotype in this population and suggest the need for much larger samples.<br><br>Copyright © 2017 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2017.12.010
ID  - ref1
ER  -