TY  - JOUR
PY  - 2018//
TI  - Childhood trauma and increased peripheral cytokines in young adults with major depressive: Population-based study
JO  - Journal of neuroimmunology
A1  - Pedrotti Moreira, Fernanda
A1  - Wiener, Carolina David
A1  - Jansen, Karen
A1  - Portela, Luis Valmor
A1  - Lara, Diogo R.
A1  - Souza, Luciano Dias de Mattos
A1  - da Silva, Ricardo Azevedo
A1  - Oses, Jean Pierre
SP  - 112
EP  - 116
VL  - 319
IS  - 
N2  - OBJECTIVE: The aim of this study was to evaluate the effect of childhood trauma in cytokine serum levels of individuals with MDD. <br><br>METHODS: This was a cross-sectional study population-based, with people aged 18 to 35. The Mini International Neuropsychiatric Interview (M.I.N.I) measured to current major depressive disorder (MDD). To evaluate traumatic experiences during childhood, the Childhood Trauma Questionnaire (CTQ) was applied. Serum TNF- α, IL-6 and IL-10 levels were measured by ELISA using a commercial kit. <br><br>RESULTS: The total sample comprised 166 young adults, of these: 40.4% were subjects with MDD and childhood trauma and 59.6% were diagnosed with MDD without childhood trauma. In relation to serum interleukin levels, subjects with childhood trauma showed a significantly higher serum IL-6 (p = 0.013) and IL-10 levels (p = 0.022) to compare no childhood trauma. Subjects with childhood trauma was observed positive correlation between serum IL-6 and physical abuse (r = 0.232, p = 0.035) and emotional abuse (r = 0.460, p ≤ 0.001). Moreover, IL-10 were positive correlation with physical abuse (r = 0.258, p = 0.013). TNF- α was not associated with childhood trauma. <br><br>CONCLUSION: Childhood maltreatment may result higher inflammation dysregulation in individuals with depression than individuals that no has childhood maltreatment.<br><br>Copyright © 2018 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-5728
UR  - http://dx.doi.org/10.1016/j.jneuroim.2018.02.018
ID  - ref1
ER  -