TY  - JOUR
PY  - 2018//
TI  - Relative performance of propensity score matching strategies for subgroup analyses
JO  - American journal of epidemiology
A1  - Wang, Shirley V.
A1  - Jin, Yinzhu
A1  - Fireman, Bruce
A1  - Gruber, Susan
A1  - He, Mengdong
A1  - Wyss, Richard
A1  - Shin, HoJin
A1  - Ma, Yong
A1  - Keeton, Stephine
A1  - Karami, Sara
A1  - Major, Jacqueline M.
A1  - Schneeweiss, Sebastian
A1  - Gagne, Joshua J.
SP  - 1799
EP  - 1807
VL  - 187
IS  - 8
N2  - Post-approval drug safety studies often use propensity scores (PS) to adjust for a large number of baseline confounders. These studies may involve examining whether treatment safety varies across subgroups. There are many ways a PS could be used to adjust for confounding in subgroup analyses. These methods have trade-offs that are not well understood. We conducted a plasmode simulation to compare relative performance of 5 methods involving PS matching for subgroup analysis, including methods frequently used in applied literature whose performance has not been previously directly compared. These methods varied whether the overall PS, subgroup specific PS or no re-matching was used in subgroup analysis as well as whether subgroups were fully nested within the main analytic cohort or not. The evaluated PS subgroup matching methods performed similarly in terms of balance, bias, and precision in 12 simulated scenarios varying size of the cohort, prevalence of exposure and outcome, strength of relationships between baseline covariates and exposure, the true effect within subgroups and the degree of confounding within subgroups. Each had strengths and limitations with respect to other performance metrics that could inform choice of method.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-9262
UR  - http://dx.doi.org/10.1093/aje/kwy049
ID  - ref1
ER  -