TY - JOUR PY - 2018// TI - Inhibition is associated with metabolic syndrome and depression through inflammation JO - Stress and Health A1 - Murdock, Kyle W. A1 - LeRoy, Angie S. A1 - Fagundes, Christopher P. SP - 457 EP - 461 VL - 34 IS - 3 N2 - Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self-report measure of depressive symptoms, and a blood draw.

RESULTS indicated that poor inhibition was associated with high interleukin-6 (IL-6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL-6.

FINDINGS suggest that IL-6 may be a mechanism linking inhibition with metabolic syndrome and depression.

Copyright © 2018 John Wiley & Sons, Ltd.

Language: en

LA - en SN - 1532-3005 UR - http://dx.doi.org/10.1002/smi.2808 ID - ref1 ER -