TY  - JOUR
PY  - 2018//
TI  - Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder
JO  - Journal of psychiatric research
A1  - Imai, Risa
A1  - Hori, Hiroaki
A1  - Itoh, Mariko
A1  - Lin, Mingming
A1  - Niwa, Madoka
A1  - Ino, Keiko
A1  - Ogawa, Sei
A1  - Ishida, Makiko
A1  - Sekiguchi, Atsushi
A1  - Matsui, Mie
A1  - Kunugi, Hiroshi
A1  - Akechi, Tatsuo
A1  - Kamo, Toshiko
A1  - Kim, Yoshiharu
SP  - 192
EP  - 200
VL  - 102
IS  - 
N2  - Posttraumatic stress disorder (PTSD) has been associated with increased inflammation, albeit with some controversy. Another key feature of PTSD is compromised function in wide-ranging cognitive domains. Increased peripheral inflammation can contribute to cognitive dysfunction, although this relationship has not been studied in patients with PTSD. Here, we examined blood inflammatory markers in adult patients with PTSD compared to healthy controls taking account of potentially confounding effects of childhood maltreatment and comorbid major depressive disorder (MDD), and explored the association between inflammation and cognition. We enrolled 40 women with PTSD, most of whom developed the disorder after interpersonal violence during adulthood, and 65 healthy control women. Diagnoses were made based on DSM-IV. History of childhood maltreatment was assessed using the Childhood Trauma Questionnaire (CTQ). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Blood samples were collected for the measurement of 5 inflammatory markers including interleukin-6 (IL-6), soluble IL-6 receptor, interleukin-1β, high-sensitivity tumor necrosis factor-α, and high-sensitivity C-reactive protein. Compared to controls, patients with PTSD showed significantly higher IL-6 levels (p = 0.009) and lower scores on all RBANS domains (all p < 0.01). IL-6 levels in patients were not significantly associated with the presence/absence of comorbid MDD or CTQ scores. IL-6 levels in patients were significantly negatively correlated with RBANS visuospatial construction (p = 0.046), language (p = 0.008), attention (p = 0.036) and total score (p = 0.008). These results suggest that elevated IL-6 is associated with PTSD and that the lower cognitive function in PTSD may be due at least partly to increased inflammation.<br><br>Copyright © 2018 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2018.04.009
ID  - ref1
ER  -