TY  - JOUR
PY  - 2018//
TI  - Longitudinal evaluation of plasma concentrations of presepsin in patients after severe trauma: a prospective observational study
JO  - Surgical Infections
A1  - Koch, Christian
A1  - Ruhrmann, Sophie
A1  - Pöhlmann, Michael
A1  - Schneck, Emmanuel
A1  - Arneth, Borros
A1  - Zajonz, Thomas
A1  - Sander, Michael
A1  - Weigand, Markus A.
A1  - Uhle, Florian
SP  - 480
EP  - 487
VL  - 19
IS  - 5
N2  - BACKGROUND: The high mortality rate of patients suffering from severe trauma is based not only on the mechanism of injury, but also on the higher risk for development of subsequent infections. Therefore, the early recognition of infection after severe trauma is of particular importance for patient outcome. However, early diagnosis is often masked by the consequences of the sterile, damage-triggered immune response. Our study sought to analyze the course of soluble CD14-subtype (sCD14-ST, presepsin) compared with clinically established inflammatory and infectious biomarkers in a cohort of patients with severe trauma. <br><br>PATIENTS AND METHODS: Between January 2015 and February 2016, 50 patients suffering from severe trauma (Injury Severity Score [ISS] > 16) were enrolled and followed up for seven consecutive days after intensive care unit (ICU) admission. Clinical routine data, signs of infection, and the inflammatory biomarkers presepsin, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) were assessed. <br><br>RESULTS: Regarding the well-established biomarkers CRP, PCT, and IL-6, we observed trauma-associated alterations (day 1: CRP 13 mg/L, interquartile range [IQR] 0-129; PCT 1.1 μg/L, IQR 0-13; IL-6 108 pg/mL, IQR 29-795), which did not correlate with the clinical development of systemic inflammatory response syndrome (SIRS), whereas elevated plasma concentrations of presepsin in the clinical course were associated with the presence of SIRS (presepsin: no-SIRS vs. SIRS p = 0.03). <br><br>CONCLUSION: Our study investigates systematically the kinetic of presepsin compared with established inflammatory and infectious markers after severe trauma. Presepsin is neither affected by the early post-traumatic nor the delayed immune response over seven days after trauma, making it a possible option as a diagnostic biomarker of infection worth further evaluation.<p />  <p>Language: en</p>
LA  - en
SN  - 1096-2964
UR  - http://dx.doi.org/10.1089/sur.2017.266
ID  - ref1
ER  -