TY  - JOUR
PY  - 2018//
TI  - Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: findings from a systematic review
JO  - Neuroscience and biobehavioral reviews
A1  - Puiu, Andrei A.
A1  - Wudarczyk, Olga
A1  - Goerlich, Katharina S.
A1  - Votinov, Mikhail
A1  - Konrad, Kerstin
A1  - Turetsky, Bruce
A1  - Herpertz-Dahlmann, Beate
SP  - 231
EP  - 246
VL  - 90
IS  - 
N2  - BACKGROUND: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. AIMS AND METHODS: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder-specific and shared IA and RI aberrant neural mechanisms. <br><br>RESULTS: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity. <br><br>CONCLUSION: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.<br><br>Copyright © 2018. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2018.04.016
ID  - ref1
ER  -