TY  - JOUR
PY  - 2018//
TI  - Complement cascade on severe traumatic brain injury patients at the chronic unconscious stage: implication for pathogenesis
JO  - Expert review of molecular diagnostics
A1  - Bao, Wangxiao
A1  - He, Fangping
A1  - Yu, Lihua
A1  - Gao, Jian
A1  - Meng, Fanxia
A1  - Ding, Yahui
A1  - Zou, Hai
A1  - Luo, Benyan
SP  - 761
EP  - 766
VL  - 18
IS  - 8
N2  - BACKGROUND: Patients who awake from severely traumatic brain injury (TBI) may remain unconscious for many years. Although behavioral assessment and functional imaging are currently used as diagnostic tools, the molecular basis underlying chronic condition has yet to be explored. <br><br>METHOD: Plasma samples were obtained at 3 time points (1, 3 and 6 months) from 18 patients with chronic disorders of consciousness who survived severe TBI, and 6 healthy volunteers. A coupled isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomics approach was used to screen differentially expressed proteins (DEPs) between patients and controls. Potential molecular mechanisms were further discussed through bioinformatics analyses. <br><br>RESULT: In total, 300 plasma proteins <1% false discovery rates were identified and 32 proteins were consistently altered between patients and controls. Biological pathway analysis revealed that the DEPs were predominantly involved in complement cascade. <br><br>CONCLUSIONS: This study discussed potential mechanisms of complement cascade underlying chronic stage in severe TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 1473-7159
UR  - http://dx.doi.org/10.1080/14737159.2018.1471985
ID  - ref1
ER  -