TY  - JOUR
PY  - 2018//
TI  - Gaze stability, dynamic balance and participation deficits in people with multiple sclerosis at fall-risk
JO  - Anatomical record (2007)
A1  - Garg, Hina
A1  - Dibble, Leland E.
A1  - Schubert, Michael C.
A1  - Sibthorp, Jim
A1  - Foreman, K. Bo
A1  - Gappmaier, Eduard
SP  - 1852
EP  - 1860
VL  - 301
IS  - 11
N2  - Despite the common complaints of dizziness and demyelination of afferent or efferent pathways to and from the vestibular nuclei which may adversely affect the angular Vestibulo-Ocular Reflex (aVOR) and vestibulo-spinal function in persons with Multiple Sclerosis (PwMS), few studies have examined gaze and dynamic balance function in PwMS. <br><br>OBJECTIVES: 1) Determine the differences in gaze stability, dynamic balance and participation measures between PwMS and controls, 2) Examine the relationships between gaze stability, dynamic balance and participation. <br><br>METHODS: Nineteen ambulatory PwMS at fall-risk and 14 age-matched controls were recruited. Outcomes included (a) gaze stability [angular Vestibulo-Ocular Reflex (aVOR) gain (ratio of eye to head velocity); number of Compensatory Saccades (CS) per head rotation; CS latency; gaze position error; Coefficient of Variation (CV) of aVOR gain], (b) dynamic balance [Functional Gait Assessment, FGA; four square step test], and (c) participation [dizziness handicap inventory; activities-specific balance confidence scale]. Separate independent t-tests and Pearson's correlations were calculated. <br><br>RESULTS: PwMS were age = 53 ± 11.7yrs and had 4.2 ± 3.3 falls/yr. PwMS demonstrated significant (p<0.05) impairments in gaze stability, dynamic balance and participation measures compared to controls. CV of aVOR gain and CS latency were significantly correlated with FGA. <br><br>CONCLUSIONS: Deficits and correlations across a spectrum of disability measures highlight the relevance of gaze and dynamic balance assessment in PwMS. This article is protected by copyright. All rights reserved.<br><br>© 2018 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-8486
UR  - http://dx.doi.org/10.1002/ar.23852
ID  - ref1
ER  -