TY  - JOUR
PY  - 2018//
TI  - Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: a case-control study
JO  - SAGE open medicine
A1  - Islam, Md Rabiul
A1  - Islam, Md Reazul
A1  - Ahmed, Imtiaz
A1  - Moktadir, Abdullah Al
A1  - Nahar, Zabun
A1  - Islam, Mohammad Safiqul
A1  - Shahid, Shelina Fatema Binte
A1  - Islam, Sheikh Nazrul
A1  - Islam, Md Saiful
A1  - Hasnat, Abul
SP  - e2050312118773953
EP  - e2050312118773953
VL  - 6
IS  - 
N2  - OBJECTIVES: Major depressive disorder is diagnosed on the basis of patient's self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls. <br><br>METHODS: We collected blood samples from 247 major depressive disorder patients and 248 controls. Serum levels of malondialdehyde and cortisol were measured by ultraviolet spectrophotometry and enzyme-linked immunosorbent assay kit, respectively. <br><br>RESULTS: We found malondialdehyde levels were significantly higher in patients than controls, with mean ± standard deviation at 4.49 ± 1.37 and 2.87 ± 0.82 µmol/L, respectively, <i>p</i> < 0.001. Cortisol levels were also found significantly higher in patients than controls, with mean ± SD at 19.22 ± 1.64 and 17.37 ± 1.34 µg/dL, respectively, <i>p</i> < 0.001. Significant negative correlation was observed between serum levels of malondialdehyde and cortisol in patients (<i>r</i> =-0.170, <i>p</i> = 0.021). Receiver operating characteristic analysis showed good diagnostic value for malondialdehyde and cortisol, with the area under the curve at 0.853 and 0.819, respectively. <br><br>CONCLUSION: The present study suggests that increased serum levels of malondialdehyde and cortisol are strongly associated with major depressive disorder. We believe elevations of malondialdehyde and cortisol in serum level arise independently and they could serve as biomarkers for major depressive disorder.<p />  <p>Language: en</p>
LA  - en
SN  - 2050-3121
UR  - http://dx.doi.org/10.1177/2050312118773953
ID  - ref1
ER  -