TY  - JOUR
PY  - 2018//
TI  - The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women
JO  - European journal of endocrinology
A1  - Van Nieuwpoort, Caroline
A1  - Vlot, Mariska
A1  - Schaap, Laura
A1  - Lips, Paul
A1  - Drent, Madeleine
SP  - 73
EP  - 84
VL  - 179
IS  - 2
N2  - OBJECTIVE: Human aging is accompanied by a decrease in growth hormone secretion and serum IGF-1 levels. Also, loss of muscle mass, strength and impairment of physical performance, ending in a state of frailty, are seen in elderly. We aimed to investigate whether handgrip strength, physical performance and recurrent falls are related to serum IGF-1 levels in community dwelling elderly. <br><br>DESIGN: Observational cohort study (cross-sectional and prospective). <br><br>METHODS: We studied the association between IGF-1 and handgrip strength, physical performance and falls in participants of the Longitudinal Aging Study Amsterdam. 1292 participants were included (633 men, 659 women). Serum IGF-1 levels were divided into quartiles (IGF-1-Q1 to IGF-1-Q4). Data on falls were collected prospectively for a period of three years. All analyses were stratified for age and physical activity and adjusted for relevant confounders. <br><br>RESULTS: Men with a low physical activity score in IGF-1-Q1 and IGF-1-Q2 of the younger age group had a lower handgrip strength compared to IGF-1-Q4. In younger more active males in IGF-1-Q2 physical performance was worse. Recurrent fallers were less prevalent in older, low active males with low IGF-1 levels. In females, recurrent fallers were more prevalent in older, more active females in IGF-1-Q2. IGF-1 quartile may predict changes in handgrip strength and physical performance in men and women. <br><br>CONCLUSIONS: Our results indicate that lower IGF-1 levels are associated with lower handgrip strength and worse physical performance, but less recurrent fallers especially in men. Associations were often more robust in IGF-1-Q2. Future studies on this topic are desirable.<p />  <p>Language: en</p>
LA  - en
SN  - 0804-4643
UR  - http://dx.doi.org/10.1530/EJE-18-0076
ID  - ref1
ER  -