TY  - JOUR
PY  - 2018//
TI  - Violent aggression predicted by multiple pre-adult environmental hits
JO  - Molecular psychiatry
A1  - Mitjans, Marina
A1  - Seidel, Jan
A1  - Begemann, Martin
A1  - Bockhop, Fabian
A1  - Moya-Higueras, Jorge
A1  - Bansal, Vikas
A1  - Wesolowski, Janina
A1  - Seelbach, Anna
A1  - Ibáñez, Manuel Ignacio
A1  - Kovacevic, Fatka
A1  - Duvar, Oguzhan
A1  - Fañanás, Lourdes
A1  - Wolf, Hannah-Ulrike
A1  - Ortet, Generós
A1  - Zwanzger, Peter
A1  - Klein, Verena
A1  - Lange, Ina
A1  - Tänzer, Andreas
A1  - Dudeck, Manuela
A1  - Penke, Lars
A1  - van Elst, Ludger Tebartz
A1  - Bittner, Robert A.
A1  - Schmidmeier, Richard
A1  - Freese, Roland
A1  - Müller-Isberner, Rüdiger
A1  - Wiltfang, Jens
A1  - Bliesener, Thomas
A1  - Bonn, Stefan
A1  - Poustka, Luise
A1  - Müller, Jürgen L.
A1  - Arias, Barbara
A1  - Ehrenreich, Hannelore
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-4184
UR  - http://dx.doi.org/10.1038/s41380-018-0043-3
ID  - ref1
ER  -