TY  - JOUR
PY  - 2017//
TI  - Preconditioned cues have no value
JO  - Elife
A1  - Sharpe, Melissa J.
A1  - Batchelor, Hannah M.
A1  - Schoenbaum, Geoffrey
SP  - e28362
EP  - e28362
VL  - 6
IS  - 
N2  - Sensory preconditioning has been used to implicate midbrain dopamine in model-based learning, contradicting the view that dopamine transients reflect model-free value. However, it has been suggested that model-free value might accrue directly to the preconditioned cue through mediated learning. Here, building on previous work (Sadacca et al., 2016), we address this question by testing whether a preconditioned cue will support conditioned reinforcement in rats. We found that while both directly conditioned and second-order conditioned cues supported robust conditioned reinforcement, a preconditioned cue did not. These data show that the preconditioned cue in our procedure does not directly accrue model-free value and further suggest that the cue may not necessarily access value even indirectly in a model-based manner. If so, then phasic response of dopamine neurons to cues in this setting cannot be described as signaling errors in predicting value.<p />  <p>Language: en</p>
LA  - en
SN  - 2050-084X
UR  - http://dx.doi.org/10.7554/eLife.28362
ID  - ref1
ER  -