TY  - JOUR
PY  - 2018//
TI  - A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study
JO  - Annals of epidemiology
A1  - Ablett, Andrew D.
A1  - Wood, Adrian D.
A1  - Barr, Rebecca
A1  - Guillot, Jordan
A1  - Black, Alison J.
A1  - Macdonald, Helen M.
A1  - Reid, David M.
A1  - Myint, Phyo K.
SP  - 557
EP  - 562.e2
VL  - 28
IS  - 8
N2  - PURPOSE: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. <br><br>METHODS: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997-2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. <br><br>RESULTS: Of 3883 participants, 3293 scored ACB = 0, 328 scored ACB = 1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB = 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals] = 1.81 [1.25-2.62]; P = 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30-7.99]; P = 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. <br><br>CONCLUSIONS: The risk of falling associated with ACB observed in older age may also extend to middle-aged women.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1047-2797
UR  - http://dx.doi.org/10.1016/j.annepidem.2018.05.011
ID  - ref1
ER  -