TY  - JOUR
PY  - 2017//
TI  - Association between polymorphisms of the DRD2 and ANKK1 genes and suicide attempt: a preliminary case-control study in a Mexican population
JO  - Neuropsychobiology
A1  - Genis-Mendoza, Alma Delia
A1  - López-Narváez, María Lilia
A1  - Tovilla-Zárate, Carlos Alfonso
A1  - Sarmiento, Emmanuel
A1  - Chavez, Adriana
A1  - Martinez-Magaña, Jose Jaime
A1  - González-Castro, Thelma Beatriz
A1  - Hernández-Díaz, Yazmín
A1  - Juárez-Rojop, Isela Esther
A1  - Ávila-Fernández, Ángela
A1  - Nicolini, Humberto
SP  - 193
EP  - 198
VL  - 76
IS  - 4
N2  - BACKGROUND: The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. <br><br>METHODS: We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. <br><br>RESULTS: Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77). <br><br>CONCLUSION: Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.<br><br>© 2018 S. Karger AG, Basel.<p />  <p>Language: en</p>
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/10.1159/000490071
ID  - ref1
ER  -