TY  - JOUR
PY  - 2018//
TI  - Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts
JO  - European psychiatry
A1  - Daray, Federico M.
A1  - Arena, Ángeles R.
A1  - Armesto, Arnaldo R.
A1  - Rodante, Demián E.
A1  - Puppo, Soledad
A1  - Vidjen, Patricia
A1  - Portela, Alicia
A1  - Grendas, Leandro N.
A1  - Errasti, Andrea E.
SP  - 19
EP  - 26
VL  - 54
IS  - 
N2  - OBJECTIVE: The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship. <br><br>METHODS: A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months. <br><br>RESULTS: At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p =  0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0-7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity. <br><br>CONCLUSION: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.<br><br>Copyright © 2018 Elsevier Masson SAS. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-9338
UR  - http://dx.doi.org/10.1016/j.eurpsy.2018.07.001
ID  - ref1
ER  -